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CT Open to Enrollment

Gene Expression Monitoring of Renal Allograft Status (GEM Tissue)

The purpose of this study is to learn more about a patient’s transplant and related complications. We will develop tests for assessing the status of the kidney transplant, as well as any potential complications. The study will help u to come up with ways to anticipate, diagnose and prognosticate problems associated with kidney transplants. The tissue collected in this study will be stored in a repository (database) to analyze for the presence of various markers believed to be involved in allograft dysfunction.

Key eligibility:

Pilot study to collect blood from research subjects allergic and non-allergic to peanut to study immune modulation with anti-IgE therapy in mice

This pilot study is collaboration between the Weill Cornell Medical College, Department of Genetic Medicine and Yale University and will examine the pathways involved in allergic response, primarily in food allergy; specifically peanut allergy.

A multicenter safety study of unlicensed, investigational cryopreserved cord blood units (CBUs) manufactured by the National Cord Blood Program (NCBP) and provided for unrelated hematopoietic stem cell transplantation of pediatric and adult patients

Cord blood (CB) is blood that is taken from the umbilical cord and placenta of healthy newborn babies after childbirth. The cord blood collected from a newborn baby is called a cord blood unit. Cord blood units are stored frozen (cryopreserved) in public cord blood banks. Approximately 10,000 cord blood transplants have been performed in children and adults for blood cancers and other blood diseases in the world. Cord blood units that meet all FDA requirements can be licensed.

The Multi-Center African American IBD Study (MAAIS)

This research study is for men and women who are of African American descent and who:

  • Have Inflammatory Bowel Disease (IBD)
  • Have a family member with IBD
  • Do not have IBD or a family member with IBD (for comparison)

The purpose of the study is to find out why inflammatory bowel disease (Crohn’s disease and ulcerative colitis) occurs in individuals and families of African-American descent. The research is being done because the characteristics of IBD in the African-American population have not been well documented.

Phase 3 Randomized Study of the Efficacy and Safety of Posaconazole versus Voriconazole for the Treatment of Invasive Aspergillosis in Adults

To compare the global clinical response of posaconazole (POS) compared to voriconazole (VOR) in the first line treatment of invasive aspergillosis (IA) at Week 6 in those subjects with proven or probable IA. The hypothesis to be tested is that the proportion of subjects achieving the global clinical response at Week 6 in the POS treatment group is noninferior to that in the VOR treatment group.

POS was shown to be effective in an open label, externally controlled salvage therapy trial of 107 patients with proven/probable aspergillosis.