For COVID-19 vaccine updates, please review our information guide. For patient eligibility and scheduling availability, please visit

A Computerized Intervention Targeting Cognitive Control Network Deficits in Depression

Clinical Trial Details

The Weill Cornell Institite of Geriatric Pyschiatry is conducting a research study of depression in adults ages 45-75 years old using a cognitive training delivered on iPads. This study is voluntary and will not influence your regular medical care. iPads are provided on loan.

Eligible individuals who agree to participate will:

  • Take part in an initial screening interview
  • Receive 4 weeks of Game-Play sessions designed to improve cognitive abilities
  • Take part in clinical interviews before starting Game-Play, immediately following 4 weeks of Game-Play, and 4 weeks following the end of Game-Play
  • Receive two MRI scans (one before starting Game-Play, and one immediately following 4 weeks of Game-Play) 

Participants will not be charged for any services. Participants will be compensated up to $575 by the end of the study. 

All information is confidential. To learn more, please call (646) 289-5204 ext. 701.

Key Eligibility: 

Inclusion Criteria

  • Ages 45-75
  • Major depression
  • Ability to participate in an MRI
  • Off antidepressants or on a stable dose for 12 weeks with plans to stay on this stable dose for five weeks
  • Capacity to consent 

Exclusion Criteria

  • Dementia or MCI
  • History or presence of psychiatric diagnosis other than unipolar, non-psychotic major depression or generalized anxiety disorder
  • Intent or plan to attempt suicide in the near future
  • MMSE score 1 SD below the mean
  • Use of psychotropic drugs or cholinesterase inhibitors 
  • Current acute medical condition 
  • History of brain illnesses 
  • Non-correctible vision, hearing, or sensory-motor impairment 

Study contact by location

Upper East Side - Manhattan


Dustin Phan
(646) 289-5204 ext. 701

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:



Open to Enrollment

Age Group