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A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

Clinical Trial Details

The purpose of this study is to compare the effect of an experimental intervention called “AKL-T01” (a mobile computerized cognitive training program) with a form of standard of care cognitive rehabilitation (“Enhanced Metacognitive Strategy Training”) on thinking skills and mood after a stroke, to see which is better. Another purpose of this study is to find out if there are changes in brain activity that occur after 6 weeks of mobile cognitive training. 
Participants will be randomized to one of the two groups. Participation entails completing mood and cognitive assessments before and after the intervention, two MRI scans, and 6 weekly coaching sessions with a clinician during the intervention period. 
This study is being done because with the information gained from this study, there is a potential to treat individuals with stroke who experience cognitive difficulties and depression symptoms. Findings from the study may inform the development of novel treatments that can be delivered in a variety of healthcare settings.
Key Eligibility: 

-Open to men and women between the ages of 50-79 who have experienced a stroke and are experiencing depression symptoms and cognitive difficulties.
-Participants must have motor function sufficient to hold and operate an iPad, which will be loaned for the duration of the study. 

Detailed eligibility will be reviewed when you contact the study team. 

Study contact by location

Upper East Side - Manhattan


Alexandra Keenan

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:






Open to Enrollment

Age Group