This clinical trial is for women aged 18 or older with a diagnosis of endometrial carcinoma on a tissue sample (biopsy) obtained at Memorial Sloan Kettering (MSK) or Weill Cornell Medicine (WCM).
Endometrial cancer is the second leading cause of death from gynecologic cancer with an estimated 10,470 women dying in the United States annually. Obesity is one of the strongest risk factors for endometrial cancer and accounts for about 50% of the cases in Europe and in the USA. Obese women (BMI >30 kg/m2) have a threefold increased risk of developing endometrial cancer compared to normal weight women. Furthermore, obesity has been associated with increased mortality in endometrial cancer.
The purpose of this study is to test any good and bad effects of an experimental diet, called a ketogenic diet, in endometrial cancer. Patients can be randomized to one of two different arms: they can either receive a standard diet, or a ketogenic diet. Randomization means that you are put into a group by chance. It is like flipping a coin.
• Women age 18 and older
• Confirmed newly diagnosed, previously untreated endometrial cancer
• BMI ≥ 25 kg/m2