Joint Clinical Trials Office

You are here

A Multi-Center Phase II Study of CC486-CHOP in Patients with Previously Untreated Peripheral T-cell Lymphoma

Clinical Trial Details

This is a phase II, multi-center study to determine the efficacy and safety of first-line CC-486 plus CHOP in patients with Peripheral T-cell Lymphoma (PTCL) who have received no prior systemic therapy. The main objective is to determine the complete response rate (CR) of CC486-CHOP in PTCL. CR rate after cycle 6 will be used for the purpose of interim efficacy analysis. 

  • The study includes 6 cycles (~18 weeks) of treatment and 2 years of follow-up. The projected end date is 12/31/2022. Patients achieving complete remission will be evaluated every 6 months for 2 years or until disease progression. Patients who have disease progression will be contacted every 6 months to assess for survival status. 
  • Standard dose CHOP will be provided on day 1 of each cycle and repeat every 3 weeks for a total of 6 cycles. 
  • CC486 at 300 mg daily will be administered orally from day -6 to day 0 for cycle 1 priming, and on days 8-21 following cycles 1-5. 
  • Patients in CR/PR following 6 cycles of treatment have the option to proceed to consolidative autologous stem cell transplant. 
  • Will continue on treatment as long as they are responding to therapy and not experiencing unacceptable side effects. 
Key Eligibility: 

   • Women and men age 18 and older with histologically confirmed diagnosis of Peripheral T-cell Lymphoma 
   • No prior systemic therapy for lymphoma 
   • Detailed eligibility reviewed when you contact the study team

Study contact by location

Upper East Side - Manhattan

Contact(s)

Amelyn Rodriguez, RN, NP
(212) 746-1362
amr2017@med.cornell.edu

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:

1711018777

ClinicalTrials.gov:

N/A

Status

Open to Enrollment

Age Group

Adult

Sponsor