This is a research study of an investigational drug called JBT-101. The study is designed to see if JBT-101 is safe in people with scleroderma. It is also designed to see if the drug causes any changes in scleroderma skin biomarkers that reflect the level of disease activity.
A skin biopsy will allow us to observe the extent to which JBT-101 changes the skin compared to placebo treatment and show whether JBT-101 alters the expression of certain genes in the skin.
This research study is being done because currently there is no effective treatment for scleroderma.
The study will take place at the Hospital for Special Surgery, though your biopsies will be performed at the dermatology department of Weill Cornell Medicine.