This is a phase 2 clinical trial for men and women with pancreatic cancer, whose disease has progressed or recurred after/on first line chemotherapy. The objective of this study is to obtain data of overall survival and overall response rate in the subject population.
Approximately 53,070 people develop exocrine pancreatic cancer each year in the United States. Exocrine pancreatic cancer typically has an aggressive growth profile and late-stage presentation of symptoms. Eighty percent of patients that are diagnosed with this cancer usually have a morality of one-year with few effective treatment alternatives. Surgical resection offers the best chance of cure. However, only 9 percent of subjects are diagnosed at the localized stage, causing the majority of pancreatic cancer cases to be unresectable.
Current available treatment are only effective in small numbers of patients. Thus, there is a need for more effective, less toxic anti-cancer agents.