Atopic dermatitis (AD) is a long-lasting inflammatory skin disease. It can cause areas of dry, thickened, raised, red skin that may crust and/or ooze. Although there is currently no cure, treatments may help control symptoms. Topical treatments aim to reduce inflammation and itching. Several options are available, but there is a need for a safe and effective topical treatment that can be applied to a large area without restrictions on how long it can be used.

This study will evaluate the safety and efficacy of tapinarof cream, 1%, a new, nonsteroidal, anti-inflammatory agent for the topical treatment for AD. Stabilizing the disease and reducing the number and severity of atopic dermatitis flares are the primary goals of treatment.

Tapinarof cream, 1% is approved by the U.S. Food and Drug Administration (FDA) for the treatment of plaque psoriasis, but it is not yet approved for the treatment of atopic dermatitis.

Participants will be randomized at a 2:1 ratio into one of two treatment groups. The first group will apply tapinarof cream, 1% and the second group will apply vehicle cream, which contains no active ingredients.

Study participation will last for 8 weeks, and participants will apply cream once daily for the duration of the study.

Participants will be expected to come into the office for 7 study visits and compensation of $50 is available for each completed visit.