The purpose of this study is to compare any good and bad effects of using aspirin after someone has completed the usual chemotherapy, surgery and/or radiation therapy for breast cancer. Some studies have suggested that aspirin may lower the risk of breast cancer coming back, but others have not, so we do not know if aspirin will help decrease breast cancer recurrence. This study will evaluate whether patients taking aspirin once per day will have a lower rate of cancer recurrence than patients taking a placebo. A placebo is a tablet that looks like the study drug (aspirin), but contains no medication.
Aspirin is approved by the Federal Drug Administration (FDA) of the United States, but is not approved for the purpose of lowering the risk of breast cancer coming back or improving survival.
As part of this study you will be asked to complete five brief questionnaires, before starting the study drug, and after two years of taking the study drug. The information from these questionnaires will be used for future studies to evaluate any lifestyle factors that may be related to inflammation. It will take about 15-30 minutes to complete all of the questionnaires.
There will be about 2936 women and men taking part in this study.