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An Open-Label Study to Assess the Anti-Tumor Activity and Safety of REGN1979, an Anti-CD20 X Anti-CD3 Bispecific Antibody, in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Clinical Trial Details

This clinical trial is for men and women with B-cell Non-Hodgkin Lymphoma (NHL).
   
The purpose of this study is to study is to assess the safety and effectiveness of odronextamab in destroying participant's cancer cells. Odronextamab is an investigational drug, which means it has not yet been approved by the U.S. Food and Drug Administration (FDA).
   
Odronextamab is a bispecific antibody designed to bridge CD20 on cancer cells with CD3-expressing T cells to facilitate local T-cell activation and cancer-cell killing. It is given through a vein (intravenous [IV] infusion) or a central line.

All participants will receive infusions of the study drug that will take at least 1 hour and could take up to approximately 4 hours.
   
Participation length depends on how participants respond to the study drug.

Key Eligibility: 
  1. A diagnosis of B-cell Non-Hodgkin Lymphoma (NHL)
  2. Have disease that has relapsed after or is refractory to at least 2 prior lines of systemic therapy

Detailed eligibility reviewed when participant contacts the study team.

 

Study contact by location

Upper East Side - Manhattan

Contact(s)

Katie Greig
212-746-6738
kag9156@med.cornell.edu

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:

2001021386

ClinicalTrials.gov:

NCT03888105

Sponsor:

R1979-ONC-1625

Status

Open to Enrollment

Age Group

Adult

Sponsor