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Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 in Patients with Advanced Prostate Cancer and Unfavorable Circulating Tumor Cell Counts

Clinical Trial Details

This clinical trial is for men with advanced prostate cancer that may have spread to other parts of the body.

Currently, once prostate cancer cells have spread from the prostate to other organs it becomes an incurable condition. The purpose of this study is to treat patients with an experimental antibody  (i.e. that has not been FDA approved) called J591 that attaches itself to a special protein on cancer cells called PSMA to try to eliminate these cancer cells (called circulating tumor cells) from the circulation.

In the initial phase of the study, 6 participants will receive the experimental J591 treatment.  Routine blood tests, research blood tests, physical exam will be performed at each visit.  Participants will also be asked to complete a questionnaire about how they are feeling.  Participants will have a radiographic scan every 3 months to check the status of their disease.

Participants who tolerate the treatment well may be re-treated at the same level every 3 months, and may continue on treatment as long as they are responding to therapy and not experiencing unacceptable side effects.

Key Eligibility: 
  • Open to men age 18 and older
  • Diagnosis of advanced prostate cancer that may have spread to other parts of the body
  • Willingness to remain on a stable hormonal therapy regimen
  • Detailed eligibility reviewed when you contact the study team

Study contact by location

Upper East Side - Manhattan

Contact(s)

Lauren Emmerich, RN
(212) 746-2651
guonc@med.cornell.edu

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:

1503015998

Status

Open to Enrollment

Age Group

Adult

Sponsor

Disease