In PEPERONI (PlacEntal PERfusion and OxygeNation Imaging), we use cutting-edge imaging to monitor how well the placenta works. The placenta, a unique and vital organ, is shared by the mother and her offspring during pregnancy. In this study, we are using advanced magnetic resonance imaging (MRI) methods to assess how the placenta performs essential functions, such as perfusion (blood flow) and oxygenation. Ultimately, PEPERONI will provide data that could enable us to develop optimal treatments for pregnancies complicated by placental failure and to ensure the best possible outcomes for future babies.

Healthy control participants will complete up to 3 non-contrast MRIs. The first between 13 and 22 weeks, the second between 22 and 30 weeks, and the third between 30 and 38 weeks of gestation. Participants in this group are able to enroll at any time between 13-38 weeks gestation.

Participants with fetal growth restriction will complete up to 2 non-contrast MRIs. The first scan will take place between 20 and 30 weeks and the second between 30 weeks and 38 weeks of gestation. Participants in this group are able to enroll at any time between 20-38 weeks gestation.

Participants with pre-eclampsia will complete one non-contrast MRI between 20 and 38 weeks of gestation.

All MRI images will be reviewed by a radiologist and participants will be notified if anything usual is found. The MRIs are provided as part of this study at no cost to participants. 

Compensation is available for eligible participants.