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Joint Clinical Trials Office

ESCAPE - Evaluation of Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography in Active Surveillance for Prostate CancEr

Clinical Trial Details

This is a prospective, multicenter, nonrandomized single-arm study assessing the diagnostic accuracy of PSMA-PET CT (Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography) in determining the absence of clinically significant prostate cancer in patients on active surveillance (AS). 

This study will be assessing the ability of PSMA-PET CT to determine the absence of clinically significant prostate cancer in patients on active surveillance (AS) with low risk and favorable intermediate-risk prostate cancer.

Patients will undergo PSMA-PET CT (Prostate Specific Membrane Antigen Positron Emission Tomography-Computed Tomography) at baseline, 12 month, and 24 month time points. 

Key Eligibility: 

 Inclusion Criteria:

  1. Males over the age of 18.
  2. Histologically confirmed low or favorable intermediate risk prostate cancer per NCCN guidelines.
  3. PSA greater than 20 ng/ml.
  4. Ability to undergo yearly PSMA-PET CT and prostate mpMRI.
  5. Ability to undergo transrectal or transperineal template and fusion prostate biopsy.

Exclusion Criteria:

  1. History of prior treatment for prostate cancer.
  2. History of systemic therapy for prostate cancer.
  3. Inability to undergo transrectal ultrasound.
  4. Life expectancy less than 10 years.
  5. Not interested in pursuing active surveillance.

Detailed eligibility will be discussed when reaching out to the study team.

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Study contact by location

Upper East Side - Manhattan

Contact(s)

Sharanya Chandrasekhar
(646) 962-2196
shc2043@med.cornell.edu

Queens

Contact(s)

Sharanya Chandrasekhar
(646) 962-2196
shc2043@med.cornell.edu

Brooklyn

Contact(s)

Sharanya Chandrasekhar
(646) 962-2196
shc2043@med.cornell.edu

Primary Investigator(s)

Timothy McClure, MD  (UES)

David A. Green, MD  (QNS)

Juan Garisto, MD  (BRK)

Protocol ID(s)

Weill Cornell Medicine IRB #:

2303025893

ClinicalTrials.gov:

NCT05948657

Status

Not Yet Recruiting

Age Group

Adult

Sponsor

  • Weill Cornell Medicine

Disease

Prostate Cancer