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Evaluating the prevalence of metabolic dysfunction associated steatotic liver disease (MASLD) during pregnancy and its influence on pregnancy outcomes and postpartum maternal health

Clinical Trial Details

The primary objective of the study is to understand how common fatty liver disease, which has a new updated name called Steatotic Liver Disease (SLD) or metabolic dysfunction associated steatotic liver disease (MASLD), is seen in pregnant people and if it affects pregnancy health and outcomes. This study assesses liver health throughout pregnancy and after delivery. 
   
Fatty liver disease, or SLD, is a silent disease without symptoms and is caused by fat collection in the liver. If left undiagnosed, it can progress to cirrhosis (liver damage due to scarring), liver cancer, or liver failure. It is also closely related to other conditions such as diabetes, high cholesterol, and being overweight, and it may influence pregnancy.

This study hopes to evaluate individuals for fatty liver disease by performing a quick ultrasound of the liver during a routine anatomy scan of the baby and by performing a fibroscan, a non-invasive, ultrasound-like test that looks at the amount of fat and scarring in the liver. A test tube of 1-2 teaspoons of blood will also be collected for analysis. If participants are found to have significant fat or scarring in their liver, they can be further evaluated.
   
The study duration lasts from the initial consent at the first prenatal visit and up until 1 year postpartum. Research visits are conducted at the initial ultrasound, 24-32 weeks prenatal visit, 6 months, and 1 year postpartum.

Key Eligibility: 
  1. Open to women between the ages of 18 and 45 who are pregnant with a single baby.

Detailed eligibility will be reviewed when you contact the study team.

Study contact by location

Upper East Side - Manhattan

Contact(s)

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:

2409027918

Status

Open to Enrollment

Age Group

Adult

Sponsor