The purpose of this study is to determine the effectiveness of a new ultrasound technique to detect cancer and/or other abnormalities in lymph nodes, small bean-shaped structures that are part of the body's immune system. Participants in this study will have at least one lymph node that may be larger than normal. 

The routine care for this is to get a biopsy, a procedure to remove a piece of tissue or a sample of cells from the body so that it can be tested in a laboratory, done through a fine needle inserted in the lymph node (US-FNA biopsy) while also undergoing an ultrasound around the area to test. An ultrasound is a painless non-invasive way to get a picture of areas inside the body using sound waves. The doctor (pathologist) will test the tissue samples obtained under a microscope to see if cancer cells or any abnormalities are present. You will receive this procedure as part of your care even if you do not participate in the study. Using these existing tests, it is possible that some abnormal or cancer cells remain in parts of the lymph nodes that were not examined under a microscope.