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Naltrexone Treatment for Prolonged Grief Disorder

Clinical Trial Details

This is a study to see how effective oral naltrexone is as treatment for prolonged grief disorder (PGD).

Prolonged grief disorder (PGD) can happen after a person close to you has died within at least 6 months (12 months for children and teens). You may feel a deep longing for the person who died and become fixated on thoughts of them. This can make it hard to function at home, work, and other important settings.

Participants will take their assigned medication for 8 weeks, with monthly visits to assess symptom severity, social connectedness, and adverse reactions.

Key Eligibility: 
  • Open to men and women above the age of 18 who meet diagnostic criteria for prolonged grief disorder

  • Participants must not have any recent history of opioid dependence, liver disease, or currently pregnant

Detailed eligibility will be reviewed when you contact the study team.

Study contact by location

Upper East Side - Manhattan


James Gang
(215) 356-0697

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:






Open to Enrollment

Age Group