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This study is being done to evaluate if a type of SRS radiation treatment called fractionated SRS (or FSRS) completed over 3 treatments to the areas of cancer in the brain delay the time until the cancer worsens or returns compared to the usual SRS given in 1 treatment.
Participants will be randomized into one of two treatment groups. Randomization is like flipping a coin and there is a 50/50 chance of being assigned to either group.
Group one will receive the usual SRS treatment and group two will receive FSRS. Image-Guided Radiation Therapy (IGRT) will be included no matter the group assignment.
After completing radiation treatment, participants will have follow-up visits in either the clinic or via telephone every 3 months for 1 year, then every 4 months for 1 year, and after 2 years, the study doctor will check in approximately every 6 months for the next 3 years.
1. Open to men and women above the age of 18 who have been diagnosed with one of the following malignancies
• Non-small cell lung cancer
• Melanoma
• Breast Cancer
• Renal cell carcinoma
• Gastrointestinal cancer
2. Participant must not have received prior radiotherapy to the brain, or have Leptomeningeal Disease (LMD)
Detailed eligibility will be reviewed when contacting the study team.