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PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)

Clinical Trial Details

The purpose of PREVENTABLE is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability, or heart disease.
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. This study seeks to assess the benefit of statins (Atorvastatin) for reducing the primary composite of death, dementia, and persistent disability and secondary composites including mild cognitive impairment (MCI) and cardiovascular events.
PREVENTABLE will randomly assign atorvastatin 40 mg daily or matching placebo daily to 20,000 community-dwelling adults 75 years of age or older without clinically evident cardiovascular disease, significant disability, or dementia, and follow them for up to 5 years (estimated median of 3.8 years). The study will enroll participants from approximately 100 US sites.
Taking part in PREVENTABLE is easy. You can join the study at home by phone or video conference, get the study drug by mail, and be followed by phone, health records or home visits, if necessary.
The study will last about five (5) years. A member of the study team will discuss the study with you and answer any questions you may have.
   You will:
   • Do brief memory and physical tests.
   • Be randomized to take the study drug or the placebo. You will take one (1) pill a day.
   • Have one (1) follow-up phone call a year. Each call should take about 30 minutes.
   These procedures can be done at home or in the clinic. You will not be charged for the study drug or any study-related procedures.

Key Eligibility: 

You may be a good fit for the study if you are 75 years or older, not taking a
   statin, and do not have:

  •     Heart disease (heart attack or stroke)
  •     Dementia
  •     A significant disability that limits your basic everyday activities

   Detailed eligibility will be reviewed when you contact the study team.

Study contact by location

Upper East Side - Manhattan


Turanoom Haque

Protocol ID(s)

Weill Cornell Medicine IRB #:






Open to Enrollment

Age Group