The purpose of this study is to determine if patients can undergo a radical prostatectomy (surgery to remove prostate gland and surrounding tissues) after Stereotactic Body Radiotherapy (SBRT, highly potent biological dose of radiation is delivered to the tumor in fewer treatments) without any major side effects to the gastrointestinal or urinary systems.
This research study is being done to identify the maximum tolerated dose of radiation that can be delivered safely to the patients before they undergo radical prostatectomy. This is a dose escalation study where first 3 patients receive 5 Gy of radiation for 5 fractions (days). They are assessed for major side effects after radiation treatment and surgery. If there are no major side effects within 30 days after surgery, another set of 3 patients are recruited who undergo 6 Gy x 5 fractions of radiation therapy. This is repeated at dose levels 7 Gy x 5 fractions and 8 Gy x 5 fractions. If at any dose level, the patients experience a major side effect within 30 days after surgery the trial will accrue the next set of patients to the previously tolerated lower dose.