Problem Adaptation Therapy for Mild Cognitive Impairment and Depression

Clinical Trial Details

This study aims to compare the effects of 15 sessions (12 weekly in first 12 weeks and 3 monthly booster sessions afterwards) of PATH-MCI (Problem Adaptation Therapy for Mild Cognitive Impairment) vs. ST-CI (Supportive Therapy for Cognitively Impaired Older Adults). Participants receive either 15 weeks of PATH-MCI or Supportive Therapy. Research assessments will be conducted at entry into the study, 6, 12, 24, 36, and 52 weeks.

Key Eligibility:

Inclusion Criteria

Between 60-85 years old
Depressed or low mood
On a stable dose of medication for at least 12 weeks with no medical recommendation to adjust dose during the 3 months of study treatment
Capacity to consent
Participation of a knowledgeable informant/study partner

Exclusion Criteria

Deemed to have a significant suicide risk as assessed by site PI and clinical team
Deemed too unstable medically or neurologically to safely enroll in a research trial
Deemed too psychiatrically unstable to safely enroll in randomized trial of psychotherapy (requiring psychiatric hospitalization at baseline for safety)
Current involvement of psychotherapy
Lack of English fluency
Lack of study partner

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Study contact by location

Upper East Side - Manhattan

Contact(s)

Joanna Pantelides
914-682-9100 x2903
jop2285@med.cornell.edu

Primary Investigator(s)

Dimitris N Kiosses, PhD (UES)

Protocol ID(s)

Weill Cornell Medicine IRB #:

1603017114

ClinicalTrials.gov:

NCT03043573

Status

Open to Enrollment

Age Group

Adult

Disease

Mental Health

Depression