Pfizer COVID-19 vaccine appointments are available to our patients. Sign up for Connect today to schedule your vaccination.

Problem Adaptation Therapy for Mild Cognitive Impairment and Depression

Clinical Trial Details

This study aims to compare the effects of 15 sessions (12 weekly in first 12 weeks and 3 monthly booster sessions afterwards) of PATH-MCI (Problem Adaptation Therapy for Mild Cognitive Impairment) vs. ST-CI (Supportive Therapy for Cognitively Impaired Older Adults). Participants receive either 15 weeks of PATH-MCI or Supportive Therapy. Research assessments will be conducted at entry into the study, 6, 12, 24, 36, and 52 weeks.

Key Eligibility: 

Inclusion Criteria

  • Between 60-85 years old 
  • Depressed or low mood
  • On a stable dose of medication for at least 12 weeks with no medical recommendation to adjust dose during the 3 months of study treatment
  • Capacity to consent
  • Participation of a knowledgeable informant/study partner 

Exclusion Criteria

  • Deemed to have a significant suicide risk as assessed by site PI and clinical team
  • Deemed too unstable medically or neurologically to safely enroll in a research trial
  • Deemed too psychiatrically unstable to safely enroll in randomized trial of psychotherapy (requiring psychiatric hospitalization at baseline for safety)
  • Current involvement of psychotherapy
  • Lack of English fluency
  • Lack of study partner 

Study contact by location

Upper East Side - Manhattan


Joanna Pantelides
914-682-9100 x2903

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:




Open to Enrollment

Age Group