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Problem Adaptation Therapy for Mild Cognitive Impairment and Depression
Clinical Trial Details
This study aims to compare the effects of 15 sessions (12 weekly in first 12 weeks and 3 monthly booster sessions afterwards) of PATH-MCI (Problem Adaptation Therapy for Mild Cognitive Impairment) vs. ST-CI (Supportive Therapy for Cognitively Impaired Older Adults). Participants receive either 15 weeks of PATH-MCI or Supportive Therapy. Research assessments will be conducted at entry into the study, 6, 12, 24, 36, and 52 weeks.
Key Eligibility:
Inclusion Criteria
- Between 60-85 years old
- Depressed or low mood
- On a stable dose of medication for at least 12 weeks with no medical recommendation to adjust dose during the 3 months of study treatment
- Capacity to consent
- Participation of a knowledgeable informant/study partner
Exclusion Criteria
- Deemed to have a significant suicide risk as assessed by site PI and clinical team
- Deemed too unstable medically or neurologically to safely enroll in a research trial
- Deemed too psychiatrically unstable to safely enroll in randomized trial of psychotherapy (requiring psychiatric hospitalization at baseline for safety)
- Current involvement of psychotherapy
- Lack of English fluency
- Lack of study partner
Study contact by location
Upper East Side - Manhattan
Primary Investigator(s)
Dimitris N Kiosses, PhD (UES)
Protocol ID(s)
Weill Cornell Medicine IRB #:
1603017114
ClinicalTrials.gov:
NCT03043573
Status
Open to Enrollment
Age Group
Adult
Sponsor
- National Institute of Aging