Problem Adaptation Therapy for Mild Cognitive Impairment and Depression

Clinical Trial Details

This study aims to compare the effects of 15 sessions (12 weekly in first 12 weeks and 3 monthly booster sessions afterwards) of PATH-MCI (Problem Adaptation Therapy for Mild Cognitive Impairment) vs. ST-CI (Supportive Therapy for Cognitively Impaired Older Adults). Participants receive either 15 weeks of PATH-MCI or Supportive Therapy. Research assessments will be conducted at entry into the study, 6, 12, 24, 36, and 52 weeks.

Key Eligibility: 

Inclusion Criteria

  • Between 60-85 years old 
  • Depressed or low mood
  • On a stable dose of medication for at least 12 weeks with no medical recommendation to adjust dose during the 3 months of study treatment
  • Capacity to consent
  • Participation of a knowledgeable informant/study partner 

Exclusion Criteria

  • Deemed to have a significant suicide risk as assessed by site PI and clinical team
  • Deemed too unstable medically or neurologically to safely enroll in a research trial
  • Deemed too psychiatrically unstable to safely enroll in randomized trial of psychotherapy (requiring psychiatric hospitalization at baseline for safety)
  • Current involvement of psychotherapy
  • Lack of English fluency
  • Lack of study partner 

Study contact by location

Upper East Side - Manhattan


Joanna Pantelides
914-682-9100 x2903

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:




Open to Enrollment

Age Group