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This is a randomized study comparing 5 radiation therapy treatments to 2 radiation therapy treatments with MRI guidance in patients with prostate cancer. The study will assess the potential benefit of limiting radiation doses received by normal tissues, namely the bladder and the rectum, with advanced MRI image guidance and to compare urinary and bowel side effects between the two treatment options. Prostate cancer cure and control and quality of life will also be examined.
Learn more about the trial details in this informational video:
There is no guarantee that patients will receive any benefits from this study. Common side effects of radiotherapy include mild pain, tiredness, diarrhea, increased urinary frequency, and erectile dysfunction. Participants may experience all, some, or none of the side effects listed, as well as other more occasionally experienced side effects. Associated risks from radiotherapy will be carefully discussed prior to participation.
Participants will be randomized into one of the study groups by chance: 5 treatments or 2 treatments. Randomization is like flipping a coin and neither the participant nor the researchers will choose the groups.
Study participation will last approximately 5 years with regular follow ups every 3 months for the first 2 years and again after completion of the study. Participants will also undergo physical exams, routine blood testing, scans, and provide urine samples as an ongoing part of the study.
Detailed eligibility will be reviewed when you contact the study team.