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This study involves the enrollment of two patient populations. For the neonatal population, we aim to develop a more accurate and efficient method for identifying abnormalities in the newborn brain using MRI imaging. MRI is the most advanced technique to examine the newborn brain, and it does not involve radiation unlike x-rays or CT. Participation will involve a 60-minute MRI scan without any sedation or contrast injections as well as approximately 2 hours dedicated to swaddling and feeding your child in preparation for the scan.
For pregnant women, we hope to improve and develop advanced MR imaging techniques in the fetal brain as well as the placenta. In doing so, we hope to improve the imaging quality of these types of exams in the clinical setting.
All MRI images will be reviewed by a radiologist and participants will be notified if anything usual is found. The MRIs are provided as part of this study at no cost to participants.
Free transportation services are available and compensation is available for eligible participants.
Neonatal population:
-Inclusion Criteria
• Healthy infants under the age of 6 weeks
-Exclusion Criteria
• Symptoms, signs, or history of any neurologic or systemic disease that might have affected the brain
• Any contraindication to MRI (e.g., claustrophobia, mechanical heart valve, pacemaker, or any other ferromagnetic implants)
Pregnant women population:
-Inclusion Criteria
• Healthy pregnant women over the age of 18 with GA ranging between 13 – 38 weeks (singleton pregnancies)
-Exclusion Criteria
• Multiple gestations
• Evidence of congenital infections
• Any contraindication to MRI (e.g., claustrophobia, mechanical heart valve, pacemaker, or any other ferromagnetic implants)
• Major maternal medical illness associated with increased risk for adverse pregnancy outcome (e.g., material malignancy, HIV, pregestational diabetes mellitus, lupus, any hypertensive disorder, cardiac disease, renal insufficiency).