The next generation of therapy for childhood cancers will be based upon in-depth molecular phenotyping that may facilitate the development of rational risk-adapted and target-based therapies. In order to support current and future molecularly-guided therapeutic trials and the basic science discovery efforts that will lead to more effective therapies, prevention, early detection and a reduction in early and late-onset toxicities, it is critical to implement universal, high-quality collection of annotated biospecimens from children with cancer.

We are doing this study to find better ways to diagnose, treat and prevent cancers in children, adolescents and young adults. To do this, we need to learn more about cancers that happen to children, adolescents and young adults. As most cancers that children get are rare, we can best learn by combining information from as many children with cancer as possible.

For this study we would like to collect some information about your cancer and treatment. We would also like to collect extra tumor from procedures done by doctors to help make a diagnosis. In some cases we would also like to collect a small amount of blood, bone marrow, or other tissue from you. This study does not decide your treatment and you can get regular cancer treatment without being in this study. However, some of the information from this study might help your doctor find out if research treatment protocols may be available for you, or in some cases, if other treatments can be recommended for you.

The study has five main parts. For each part, you decide whether or not you want to participate.

The five parts of this study are:

1. Childhood Cancer Registry: In this part of the study, we collect basic information like your name, address, phone number, birthday, race and ethnicity, type of cancer, medical history, whether your mother had any medical problems related to being pregnant with you, and other important medical information.

2. Eligibility Screening: In this part of the study, we do some imaging and other tests so we can understand what kind of cancer you have and where in the body it is. We also may do special tests on tumor removed by your doctors to help make the diagnosis.

3. Tracking Outcome: In this part of the study, we collect basic information about the treatment you received and how your cancer responded.

4. Biobanking for future research: In this part of the study we save tissue to be used by researchers later.

5. Contact for future research: In this part of the study we are just asking your permission to contact you if there is a future research study about childhood cancer that you might be interested in for your child.