This study is being done to find better ways to diagnose, treat and prevent cancers in children, adolescents, and young adults. To do this, we need to learn more about cancers that happen to these groups. As most cancers that children get are rare, we can best learn by combining information from as many children with cancer as possible.

This study will collect some information about participants’ cancer and their treatment, including extra tumor samples from procedures done by doctors to help make a diagnosis. In some cases, a small amount of blood, bone marrow, or other tissue will be collected.   

The study has six different parts Eligibility Screening, Molecular Characterization, and Biobanking for Future Research, Tracking Outcome, Childhood Cancer Registry and Contact for future Research.  Consenting for all parts requires two separate consents. Participants can consent for the first three parts (Eligibility Screening, Molecular Characterization, and Biobanking for Future Research) with the first consent. The second consent covers Tracking Outcome, Childhood Cancer Registry and Contact for Future Research.

Eligibility Screening: Obtaining tumor, blood or bone marrow samples, doing imaging studies (such as MRI, CT or PET scans) or performing other medical tests will be done to provide information on the status of a participants health and to understand their cancer.

Molecular Characterization Initiative: The study team will let participants know if they are part of this group, which entails detailed genetic testing on tumors and the blood.
   
Biobanking for future research: Tissue will be saved to be used by researchers later. As part of regular medical care, doctors took or are planning to take some of the tumor, bone marrow or cerebrospinal fluid (CSF) to find out the type of cancer. If there is leftover tumor, tissue, or CSF that is not needed for diagnosis or regular medical care, the study team would like to keep some for special research studies. The results of tissue (specimen) bank research may help find new ways to learn about, prevent, or treat cancer and other diseases.
   
Tracking Outcome: Basic information will be collected about the treatment received and how the cancer responded to that treatment. This includes things like what kind of chemotherapy, surgery, radiation treatment or other therapy was given, whether there were serious side effects, and whether or how well the treatment worked.
   
Childhood Cancer Registry: Information on family history, medical information, name, birth location, race and ethnicity, and parent/guardian details will be collected to help better understand childhood cancers.

Contact for Future Research: In this part of the study, we are asking permission to contact participants if there is a future research study about childhood cancer that they might be interested in.

Since this study is just collecting information and samples at the time of regular medical care, it will not take any extra time to be in the study. The study itself will go on for many years.