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Joint Clinical Trials Office

Tissue Collection for Drug Screening and Bioanalysis

Clinical Trial Details

Cancers behave differently in different patients; thus, not all therapies will work for everyone. By identifying biological pathways and specific genetic alterations in different cancers, patient treatments can be better tailored, resulting in a personalized approach to treatment.

The purpose of this study is to collect tissue, blood samples, and cerebrospinal fluid (CSF) to perform a series of molecular, cellular, and genomic analyses. This will allow researchers to better understand the tumor, identify the specific pathways or genes that drive its growth, and potentially develop better tests and treatments for pediatric brain cancers.

Participation in this research will be a single visit unless otherwise noted.
   

Key Eligibility: 

Cohort 1: Tumor patients undergoing neurosurgery procedure

  • A. Participant has presented with a suspected/confirmed neoplastic CNS lesion and is undergoing a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be removed.
  • B. There must be tissue available in excess of that required by neuropathology for diagnostic purposes.
  • C. Participants of all ages included.

Cohort 2: Non-tumor patients undergoing neurosurgery

  • A. Participant is between 4 weeks and 21 years of age and is undergoing a neurosurgical procedure at WCMC.
  • B. Participant does not have a CNS tumor diagnosis.
  • C. Participant should not be pregnant at the time of enrollment.

 Cohort 3: Autopsy tumor tissue donation 

  •  A. Participants of all ages included
  • B. Participant has been diagnosed with a neoplastic CNS lesion at the time of passing.

   
   

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Study contact by location

Upper East Side - Manhattan

Contact(s)

Pediatric Neurosurgery Team
212-746-2363
pediatricneurosurgery@med.cornell.edu

Primary Investigator(s)

Jeffrey Greenfield, MD, PhD

Protocol ID(s)

Weill Cornell Medicine IRB #:

2001021289

ClinicalTrials.gov:

NCT04852354

Status

Open to Enrollment

Age Group

Adult , Pediatric

Sponsor

  • Weill Cornell Medicine

Disease

Brain lesions
Brain Tumor