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Tomosynthesis Mammographic Imaging Screening Trial (TMIST)

Clinical Trial Details

The purpose of this clinical trial is to determine whether screening for breast cancer with tomosynthesis mammography is superior to digital mammography. To determine that, we are studying whether women who are screened for breast cancer with tomosynthesis mammography have fewer advanced breast cancers compared with the number of such cancers found when women are screened for breast cancer with digital mammography. This study will also compare whether there is a difference in the number of additional tests recommended after tomosynthesis mammography and digital mammography. 

Key Eligibility: 

You must be: 

  • 45-74 years of age 
  • Scheduled for a screening mammogram 

You must not: 

  • Be pregnant, intend to be pregnant, or lactating 
  • Have symptoms of breast disease 
  • Have had a screening mammogram in the last 11 months 
  • Have a history of breast cancer 
  • Currently have breast implants or other breast enhancements 

Study contact by location

Upper East Side - Manhattan


Eileen Wang Chang
(212) 746-6248

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:




Open to Enrollment

Age Group