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Understanding the Dynamic Interactions Between Tau Pathology and Microgliamediated Inflammation in Alzheimer's Disease

Clinical Trial Details

The purpose of this study is to investigate the relationships between neuroinflammation and Alzheimer’s disease (AD). Neuroinflammation is inflammation that occurs in the brain. Certain cells in the brain called microglia are involved in regulating inflammation. The accumulation of certain abnormal proteins, such as tau, have been implicated in AD. Tau may promote inflammatory reactions by microglial cells.

We think that measuring the activity of microglia cells with experimental imaging techniques might be able to help us better understand the extent to which neuroinflammation is involved in the progression of AD. 

Key Eligibility: 

Inclusion Criteria: 

  • Ability to provide signed informed consent (with or without Legal authorized representative, as appropriate) and willingness to comply with protocol requirements
  • Male or female 60-90 years of age
  • Documentation of clinical diagnosis of one or more of the following: subjective memory complaints, mild cognitive impairment, Alzheimer’s Disease

Exclusion Criteria: 

  • A questionnaire-based screen reveals confounding neurological disease, or the MRI over-read by staff radiologists reveals the same
  • Neurological co-morbidities unrelated to neurodegeneration, including, but not limited to stroke, hydrocephalus or epilepsy
  • Gene variation that would inhibit binding to study drug (DPA713) and/or clinical factors that would compromise statistical analysis of the PET
  • Any metal in the body above the waist, claustrophobia, unlikely to remain still during examinations or other contraindication for MRI (i.e. ferromagnetic implants, pace-maker, etc.) 
  • Other unspecified reasons that, in the opinion of investigators, make the subject unsuitable for enrollment 

Study contact by location

Upper East Side - Manhattan


Meagan Cea
(212) 746-6055

Primary Investigator(s)

Protocol ID(s)

Weill Cornell Medicine IRB #:



Open to Enrollment

Age Group