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The purpose of this study is to investigate the relationships between neuroinflammation and Alzheimer’s disease (AD). Neuroinflammation is inflammation that occurs in the brain. Certain cells in the brain called microglia are involved in regulating inflammation. The accumulation of certain abnormal proteins, such as tau, have been implicated in AD. Tau may promote inflammatory reactions by microglial cells.
We think that measuring the activity of microglia cells with experimental imaging techniques might be able to help us better understand the extent to which neuroinflammation is involved in the progression of AD.