The purpose of this prescreening study is to identify people that may be eligible for future clinical trials that test new drugs for Alzheimer’s disease.

We hope to learn about the efficacy of using Bone Marrow Aspirate Concentrate (BMAC) during temporomandibular joint (TMJ) arthroscopy compared to standard arthroscopic procedures with corticosteroid (CS) injections. We are recruiting patients that have a diagnosis of pain (arthralgia) of the temporomandibular joint (TMJ) that has failed to respond to conservative treatment.
   
Participants will be randomized to receive either BMAC or CS injection during TMJ arthroscopy. There is an equal chance of you being in either intervention group.

The overall goal of this study is to understand patients’ perceptions of dashboard-based screening and intervention matching. Dashboard-based screening and intervention matching means that we are using the collection of patients’ responses to surveys to match patients to studies that may be fitting or beneficial to them. These studies are then introduced to the patient, and they can choose to participate. 
   

In this study, we are trying to improve treatment of Favorable Histology Wilms Tumors (FHWT). Wilms Tumor is the most common type of kidney cancer in children, and FHWT is the most common subtype.

This study involves new treatments and some usual treatments for FHWT. We will use results of biology tests to make treatment decisions. We may also use the tumor’s early response to treatment to guide further therapy.

This clinical research study aims to investigate the safety and efficacy of a study drug called vonoprazan, a potassium-competitive acid blocker, for treating Eosinophilic Esophagitis (EoE). EoE is characterized by an excessive presence of eosinophils in the esophagus, leading to inflammation and symptoms such as difficulty swallowing, chest pain, and nausea. The main objective of the study is to assess the effectiveness of vonoprazan in alleviating the symptoms of EoE and improving patient outcomes.

The purpose of this study is to evaluate the safety and effectiveness of AAA817 and an Androgen receptor pathway inhibitor (ARPI) given compared to the standard of care options.
   
AAA817 is experimental, which means it is being tested and is not yet approved by the United States Food and Drug Administration (FDA).
   
In this study, AAA817 will be given intravenously (meaning through a needle in the vein directly into the blood). The Androgen receptor pathway inhibitor (ARPI) will be given orallly.

This project hopes to learn about the impact of high cholesterol in patients with primary biliary cholangitis. Participants wil have primary biliary cholangitis and elevated cholesterol levels.

Primary biliary cholangitis is a chronic, cholestatic liver disease that results in progressive fibrosis and ultimately cirrhosis 

This study is being done to see if receiving the medication triptorelin during chemotherapy reduces the chances of ovarian damage compared to having the chemotherapy without receiving triptorelin in women under the age of 40 with cancer.

Protecting the ovaries during chemotherapy is not part of the usual approach to cancer treatment. Some patients may have eggs or ovarian tissue removed and frozen before the beginning of treatment.

The purpose of this study is to evaluate the safety and effectiveness of Ziftomenib (KO-539) in patients with acute myeloid leukemia (AML). This study has 2 separate investigations (Nonintensive and Intensive). 

This clinical trial is for adults who have extensive stage small cell lung cancer (ES-SCLC) for which they have received no treatment.
   
The purpose of this study is to evaluate the effects of BNT327 (the “study drug”) when combined with chemotherapy (etoposide plus carboplatin), compared with standard of care, a drug called atezolizumab in combination with chemotherapy (etoposide plus carboplatin), to find out the following: