The purpose of this study is to compare two radiation treatment schedules: one delivers a higher dose of radiation per treatment for fewer treatments over a shorter length of time (SBRT); the other delivers a lower dose of radiation per treatment but for more treatments over a longer time. Short duration radiation therapy instead of the usual treatment could prevent your cancer from coming back.

This study is being done to evaluate if the combination of ASTX727 and venetoclax works better than ASTX727 alone at decreasing the signs and symptoms of bone marrow cancer, known as myelodysplastic/myeloproliferative neoplasm (MDS/MPN).

We are doing this study because we want to find out if this approach is better or worse than the usual approach for bone marrow cancer called chronic myelomonocytic leukemia (CMML) or a less common form called non-CMML MDS/MPN. The usual approach is defined as care most people get.

The primary objective of the study is to understand how common fatty liver disease, which has a new updated name called Steatotic Liver Disease (SLD) or metabolic dysfunction associated steatotic liver disease (MASLD), is seen in pregnant people and if it affects pregnancy health and outcomes. This study assesses liver health throughout pregnancy and after delivery. 
   

The purpose of this study is to evaluate the efficacy of adding cusatuzumab to venetoclax plus azacitidine (VAC) compared to venetoclax plus azacitidine (VA) alone for patients with acute myeloid leukemia (AML).

Cusatuzumab is considered investigational which means it has not been approved by the U.S. Food and Drug Administration (FDA). Azacitidine and venetoclax are both FDA-approved.   

This is a randomized clinical research study examining an investigational treatment called CVN424 in patients with Parkinson's Disease (PD).

This study aims to examine the safety and usefulness of low-intensity focused ultrasound (LIFU) in treating people with Opioid Use Disorder (OUD) and/or other substance use disorders (SUDs).

This phase 3 program is evaluating the efficacy and safety of tulisokibart in participants with moderately to severely active Crohn’s Disease.
   

This clinical trial is for adults who have a certain type of cancer called large B-cell lymphoma (LBCL) and have not yet received treatment for it.
   

The purpose of this prospective randomized trial is to evaluate the serration angioplasty effect in below the knee arteries with calcified plaque when the Serranator Serration Angioplasty Balloon is used as compared to a conventional balloon angioplasty.

Conventional balloon angioplasty is a regularly used approach. The Serranator Angioplasty Nalloon is U.S. Food and Drug Administration (FDA) approved and commercially available.

The purpose of the trial is to find out if an investigational device called the “Boomerang Catheter System,” containing Boomerang Catheter and Boomerang Power Controller works for a new use in the leg and to monitor the safety in treating blockages in the arteries located behind and below the knee down to the small arteries located at the joint of the leg and foot in patients suffering from low blood flow to the lower leg.