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A Phase 3, Open-Label, Randomized, 2 Part Study Comparing Gedatolisib in Combination with Palbociclib & Fulvestrant to SoC Therapies in Patients with HR+ HER2- Advanced Breast Cancer Previously Treated with a CDK4/6 Inhibitor with Non-Steroidal AI Therapy

This clinical trial is for adult participants who have breast cancer that is advanced or that has spread to other parts of the body.
   
The purpose of this study is to evaluate the safety and effectiveness of a new drug called gedatolisib when combined with other cancer drugs, compared to the standard of care. The standard of care is a drug or drug combination that is usually given to patients with breast cancer. Gedatolisib, which is intended to slow or stop the growth of cancer, is not yet approved by the United States Food and Drug Administration (FDA).

A multiomics profiling study to classify the origin of Cancers of Unknown Primary (CUP)

This study is for men and women who have been diagnosed with cancer of unknown primary (CUP) origin.
   
The purpose of this study is to understand specific changes in the genes of patients with cancers of unknown primary, a relatively common disease that accounts for about 3–9% of all cancer diagnoses. In the USA alone, this occurs in more than 80,000 patients every year.

Blood Coagulation in Cancer Patients

This study is for men and women recently diagnosed with and/or under treatment for cancer at Weill Cornell Medicine/NewYork-Presbyterian Hospital.
   

An Open-label, First-in-human, Dose-escalation Study of SAR443579 Administered as Single Agent by Intravenous Infusion in Patients With Relapsed or Refractory Acute Myeloid Leukemia, B-cell Acute Lymphoblastic Leukemia or High-risk myelodysplasia

The purpose of this study is to test a new experimental drug called SAR443579 for the treatment of participants with relapsed or refractory acute myeloid leukemia (R/R AML), B-cell acute lymphoblastic leukemia (B-ALL), and high risk-myelodysplasia (HR-MDS).

Experimental means that it has not been approved by the US Food and Drug Administration (FDA) to be prescribed to patients.

Phase II study of Polatuzumab vedotin in combination with chemotherapy in subjects with Richter’s Transformation

This clinical trial is for men and women with a diagnosis of chronic lymphocytic leukemia (CLL) and Richter’s transformation. Richter’s transformation occurs when CLL changes into a type of diffuse large B cell lymphoma (DLBCL).
   
The purpose of this study is to evaluate the safety and efficacy of the investigational drug, Polatuzumab vedotinin, in combination with a standard chemoimmunotherapy regimen.

Next-Generation Sequencing to Evaluate Transcriptomic Changes Associated with H. pylori Infection and Gastric Cancer Carcinogenesis

This clinical trial is for non-gender specific adults ages 18-100 years old with H.pylori infection.
   
The purpose of this study is to learn how the H.pylori infection can lead to cancer as well as provide information on possible intervention treatments that can be administered prior to the development of advanced cancer.
   

Connect® Myeloid: The Myelofibrosis (MF), Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Disease Registry

This is an observational study for people with myelofibrosis (MF), lower risk or higher risk myelodysplastic syndromes (MDS), Idiopathic Cytopenia of Undetermined Significance (ICUS), and acute myeloid leukemia (AML).

Comparison of Venipuncture Serum Prostate Specific Antigen (PSA) with Point of Care Fingerstick Blood Draw Rapid Test for PSA (RT-PSA)

The clinical trial is for men, with or without a diagnosis of prostate cancer, who are about to undergo a routine prostate-specific antigen (PSA) test.
   
The purpose of this study is to see if a PSA value derived from the Point of Care Rapid Test for is similar to the value obtained from a certified laboratory. 
   
Participants who are visiting their physician to have their blood drawn to measure a PSA value will, within 1 hour of the blood test, also have a finger stick blood draw with a drop of blood placed on the measurement strip. 

An Open-Label, Multicenter, Phase 1/2 Study of RP1 as a Single Agent and in Combination With PD1 Blockade in Patients With Solid Tumors

This is a clinical trial for adults who have been diagnosed with Melanoma or Non-Small Cell Lung Cancer (NSCLC).

The purpose of this study is to test the safety and efficacy of an investigational drug RP1 when it is injected into a tumor on its own as well as in combination with nivolumab for the treatment of certain types of solid tumors.