The purpose of this study is to test the good and bad effects of a drug called M3814 in combination with the drug avelumab and radiation therapy for advanced/metastatic solid tumors and hepatobiliary malignancies.

This clinical trial is for adults who have metastatic breast cancer with a BRCA 1 or BRCA 2 mutation of the tumor detectable by blood or tumor tissue.
   

This clinical trial is for men and women who have a solid tumor cancer (not a blood cancer) that has worsened and has not responded to at least one prior cancer treatment. Participants’ tumor DNA must also have an error in one of the genes associated with the homologous recombination (HR) pathway including but not limited to BRCA1 or 2 (Breast Cancer 1 or 2).
   

This clinical trial is for men and women who have been diagnosed with colorectal cancer that has spread to their liver and are eligible for standard of care surgery to remove tumors in their liver.
   

This clinical trial is for men and women who have been diagnosed with an advanced type of multiple myeloma (MM) and their cancer has returned after taking 3 or more other cancer medications (this is called relapsing) or those medications did not work (this is called refractory). Other study sites are also enrolling patients who have non-Hodgkin’s lymphoma (NHL), but Weill Cornell Medicine is only enrolling participants who have multiple myeloma (MM).
   

The goal of this study is to better understand the biology underlying plasma cell disorders.

To accomplish this goal, we have created a database-biorepository which is being used by investigators at Weill Cornell Medicine and their collaborators. By studying the clinical course of patients with plasma cell disorders, and by performing basic laboratory studies using their tissue, we hope to improve patient care.

The purpose of this study is to better understand how well the medication REBYOTA is working to prevent recurrence of CDI (Clostridioides Difficile Infection) among adults following antibiotic treatment. The study also aims to understand patient-reported outcomes and health care utilization (e.g., doctors’ visits, and hospitalizations) after receiving REBYOTA. 

REBYOTA prevents recurrence of CDI among adults following antibiotic treatment and this drug is approved by the U.S. Food and Drug Administration (FDA).

This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) for the treatment of advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, and gastric adenocarcinoma.

This is a prospective study for the long-term follow-up (LTFU) of safety and efficacy for all pediatric and adult participants exposed to Gene-modified (GM) T cell therapy participating in a previous Celgene-sponsored or Celgene alliance partner-sponsored study.

This is a Phase 2 randomized, open-label, two-part, multicenter study with a safety run-in to evaluate efficacy and safety of DKN-01 plus FOLFIRI/FOLFOX and bevacizumab versus standard of care (SOC) [FOLFIRI/FOLFOX and bevacizumab] as second-line treatment of advanced colorectal cancer patients.

In Parts A and B, approximately 150 evaluable adult advanced colorectal cancer patients with measurable disease who have radiographically progressed during or following 1 line of systemic treatment will be enrolled in the study.