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Diet and Meal Timing in Patients with Non-Alcoholic Fatty Liver Disease: A Pilot Study

The purpose of this research study is to create diet and meal timing in patients with Non-Alcoholic Fatty Liver Disease. Time-Restricted Eating (TRE) is a form of caloric restriction through daily prolonged fasting that has been shown to lead to weight loss, improved glucose regulation, and suppression of inflammation. This study aims to test the hypothesis that TRE will add additional benefit in the treatment of NAFLD on top of standard of care diet and lifestyle modifications.

Pain Reduction Using NEurostimulation (PRUNE) Study

The purpose of this study is to evaluate the usefulness of an at home small battery-operated device using a headband that delivers transcranial Direct Current Stimulation (tDCS) to see if it reduces pain in kidney disease patients receiving hemodialysis (HD) treatments.

The Janus Rectal Cancer Trial: A Randomized Phase II Trial Testing the Efficacy of Triplet Versus Doublet Chemotherapy to Achieve Clinical Complete Response in Patients with Locally Advanced Rectal Cancer

This study is being done to evaluate if by adding a 3rd drug (irinotecan) to the standard regimen of FOLFOX or CAPOX given following long-course chemoradiation for patients with locally advanced rectal cancer can increase the clinical complete response rate (tumor disappears by exam, endoscopy, and imaging).

The usual approach for patients who are not in a study is treatment with chemoradiation followed by radical surgery then possibly chemotherapy after surgery, or a combination of chemotherapy then chemoradiation then radical surgery.

A Pragmatic Observational Study of Biometrics Collected by Wearable Technology in Patients with Liver Disease

This is a prospective pilot study evaluating the ability of an Oura fitness tracker to evaluate the various physiologic changes that happen in chronic liver disease (cirrhosis).

Inventiva 337HNAS20011 (NATiV3): A randomised, double-blind, placebo-controlled, multicentre, Phase 3 study evaluating efficacy and safety of lanifibranor followed by an active treatment extension in adult patients with non-cirrhotic non-alcoholic steatoh

This study is for men and women who have been diagnosed with non-cirrhotic nonalcoholic Steatohepatitis (NASH) and liver fibrosis. This study will test the experimental/investigational drug named lanifibranor to help in the treatment of non-cirrhotic non-alcoholic steatohepatitis (NASH) and fibrosis 2 (F2)/fibrosis 3 (F3) stage of liver fibrosis (the amount of scarring), and how safe it is to use in people.

A Phase II Randomized Control Trial of Triapine Plus Lutetium Lu 177 Dotatate Versus Lutetium Lu 177 Dotatate Alone for Well-Differentiated Somatostatin Receptor-Positive Neuroendocrine Tumors

This study proposes to test if the study drug triapine is an effective radiation sensitizer that can be safely combined with peptide receptor radionuclide therapy (PRRT) and can improve antitumor activity of the PRRT Lutetium Lu 177 Dotatate for well-differentiated somatostatin receptor-positive neuroendocrine tumors.

Register-Dependent Variability of Pitch and Amplitude Control in Singers

This study aims to learn and evaluate the relationship between vocal register, pitch, and loudness by investigating how vocal pitch changes with variations in loudness.

Participants will be required to sing in both chest register and head registers, with their vocal pitch being measured twice. They will also undergo a free laryngoscopy.

The total time commitment is approximately 1 hour and those who complete the study will receive $100 for their participation.

Study of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced Solid Cancer Types

This clinical trial is for men and women who have an advanced cancer that has not responded or has stopped responding to treatment with a class of drugs called programmed cell death protein-1 (PD-1) or programmed cell death-ligand 1 (PD-L1) inhibitors.
   

A Real World Study of eCoin® for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)

The purpose of this study is to provide real world information about an implantable device called “eCoin” to treat urgency urinary incontinence for people experiencing the accidental leakage of urine.

For those not well treated by drugs and other alternatives, percutaneous tibial nerve stimulation (PTNS) and sacral nerve stimulation (SNS) are other therapies approved in the United States by the Food and Drug Administration (FDA). In the U.S., PTNS is approved for treatment of overactive bladder and the associated symptoms described above in the Introduction.