This is a multi-center Phase 1/2 clinical trial to evaluate the safety, prostate-specific antigen (PSA) response, and immunogenicity of the VTP850 prime-boost immunotherapeutic in men with biochemical recurrence of prostate cancer after definitive local therapy. 
   
VTP-850 is considered investigational, which means it has not been approved by the U.S. Food and Drug Administration.

The purpose of this study is to determine if endothelial cells derived from the human umbilical vein are safe for use in conjunction with fistulotomy for the treatment of simple anal fistulas. Endothelial cells are a special kind of cell in the body that line the inside surface of blood vessels. The goal of the study is to evaluate the preliminary safety of human umbilical vein cells in anal fistula healing.

xBar is an investigational device intended for post-op monitoring of patients undergoing gastrointestinal (GI) surgery. The device is comprised of a surgical drain with embedded electrodes, connected to a small electronic device that records and relays data from the electrodes. The collected data is processed for early detection of complications.

Investigational means that xBar has not been approved by the U.S. Food and Drug Administration (FDA).

The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort will include those who are disinclined to have their treatment choice randomized but are willing to contribute information about their outcomes.

This study is evaluating an investigational device (also known as the “study device”) called GATT-Patch as a possible management of minimal to moderate bleeding during liver surgery. An investigational device is one that has not been approved by the United States (US) Food and Drug Administration (FDA). 
   

The purpose of this study is to calculate the amount of oxygen in bowel tissue with the ViOptix Intra.Ox™ device. The creation of a healthy and safe colorectal anastomosis, where the colon is attached to the remainder of the rectum after a portion of it has been removed, requires good blood supply and oxygenation to the bowel tissue. The device in this study is intended to non-invasively measure the percent of oxygen in the bowel tissue.

The main purpose of the study is to assess the safety and tolerability of AZD9829 in different dose levels for patients with hematological malignancies.

AZD9829 is considered investigtional, which means it is not approved by the U.S. Food and Drug Administration (FDA). 

This Phase Ib/III study (CAPItello-292) aims to evaluate the efficacy, safety and the degree of added benefit of capivasertib combined with CDK4/6i and fulvestrant in participants with locally advanced (inoperable) or metastatic HR+/HER2- breast cancer.

The purpose of this research study is to better understand the causes of fatty liver recurrence and the development of metabolic illnesses such as diabetes, high blood pressure, weight gain, and abnormal cholesterol levels in patients who have undergone liver transplantation.

This clinical trial is for men and women with Newly Diagnosed FLT3 Mutated Acute Myeloid Leukemia (AML).