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CT Open to Enrollment

Prognostic Significance of Circulating Tumor Cells in Prostate Cancer: A Pilot Study

The purpose of this study is to investigate the role of circulating tumor cells (CTCs) in patients with prostate cancer. Patients who have prostate cancer can develop metastases where the cancer spreads outside the prostate into other organs. It is believed that this occurs from tumor cells that circulate in the bloodstream.

A Phase 3, Randomized, Double-blind, Placebo-controlled Multicenter Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients with Cold Agglutinin Disease (CAD)

The purpose of this study is to test whether a new investigational drug called Pegcetacoplan can reduce some of the symptoms experienced by patients with cold agglutinin disease (CAD), also sometimes known as cold antibody hemolytic anemia. Researchers also want to test the tolerability of the drug to make sure it is safe for people with CAD to use.

Investigational means that the study drug is currently being tested and it has not yet been approved by the US Food and Drug Administration (FDA). 

Phase I, Open Label Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Expansion, Persistence and Clinical Activity of UCART123 Administered in Patients With Relapsed/Refractory AML or Newly Diagnosed High-Risk AML

This is a clinical trial for adults diagnosed with relapsed (has come back) or refractory (has not responded to treatment) acute myeloid leukemia (AML).

The goal of Phase 1 of this study is to test the safety and tolerability of up to 5 different doses of the investigational medication UCART123 and to find the best dose of UCART123 that can be given to patients with AML that is relapsed or refractory.   

An Open-Label Study to Assess the Anti-Tumor Activity and Safety of REGN1979, an Anti-CD20 X Anti-CD3 Bispecific Antibody, in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

This clinical trial is for men and women with B-cell Non-Hodgkin Lymphoma (NHL).
   
The purpose of this study is to study is to assess the safety and effectiveness of odronextamab in destroying participant's cancer cells. Odronextamab is an investigational drug, which means it has not yet been approved by the U.S. Food and Drug Administration (FDA).
   

A Phase 1b/3 Double-Blind, Randomized, Active-Controlled, 3-Stage, Biomarker Adaptive Study of Tazemetostat or Placebo in Combination with Lenalidomide Plus Rituximab in Subjects with Relapsed/Refractory Follicular Lymphoma

This clinical trial is for participants with relapsed/refractory follicular lymphoma.

The purpose of this study is to understand more about whether the investigational drug, tazemetostat, in combination with lenalidomide and rituximab will be a useful treatment for people with relapsed/refractory follicular lymphoma. An investigational drug means that it has not yet been approved by the United States Food and Drug Administration (FDA).

An Investigation of a Working Memory Training Program for Neurological Surgery Patients with Various Diagnoses

This study is for men and women who have undergone surgery for a neurological condition, including brain tumors, vascular disorders such as aneurysms or arteriovenous malformations, or elective surgery for epilepsy or Chiari malformation.
   

A Phase 3, Open-Label, Randomized, 2 Part Study Comparing Gedatolisib in Combination with Palbociclib & Fulvestrant to SoC Therapies in Patients with HR+ HER2- Advanced Breast Cancer Previously Treated with a CDK4/6 Inhibitor with Non-Steroidal AI Therapy

This clinical trial is for adult participants who have breast cancer that is advanced or that has spread to other parts of the body.
   
The purpose of this study is to evaluate the safety and effectiveness of a new drug called gedatolisib when combined with other cancer drugs, compared to the standard of care. The standard of care is a drug or drug combination that is usually given to patients with breast cancer. Gedatolisib, which is intended to slow or stop the growth of cancer, is not yet approved by the United States Food and Drug Administration (FDA).

A multiomics profiling study to classify the origin of Cancers of Unknown Primary (CUP)

This study is for men and women who have been diagnosed with cancer of unknown primary (CUP) origin.
   
The purpose of this study is to understand specific changes in the genes of patients with cancers of unknown primary, a relatively common disease that accounts for about 3–9% of all cancer diagnoses. In the USA alone, this occurs in more than 80,000 patients every year.

Blood Coagulation in Cancer Patients

This study is for men and women recently diagnosed with and/or under treatment for cancer at Weill Cornell Medicine/NewYork-Presbyterian Hospital.