The purpose of this study is to determine whether the study drug, Rusfertide, is safe and effective for treating Polycythemia Vera for those that require routine phlebotomies (removal of red blood cells) to control their disease.

Participants in this study should have previously participated in a study in which Rusfertide (also known as PTG-300) was being studied. Participants will continue to receive Rusfertide in this study.

The purpose of this study is to see if ABBV-787 (the study drug) is safe and to determine if ABBV-787 has an effect on relapsed or refractory (R/R) Acute Myeloid Leukemia (AML). This study is for patients with Acute Myeloid Leukemia (AML) that have relapsed or are refractory (R/R; meaning they have returned, grown, or progressed during or after one or more prior treatments).

ABBV-787 is considered investigational which means it has not yet been approved by the U.S. Food and Drug Administration (FDA).

In this clinical trial, we hope to learn the effectiveness of cemiplimab with chemotherapy or cemiplimab with stereotactic body radiation therapy (SBRT) as treatment for clinical stage IB-III (N2) non-small cell lung cancer prior to surgery and cemiplimab for one year following surgery. 

Cemiplimab is approved by the U.S. Food and Drug Administration (FDA) for advanced disease, however, it is considered investigational in this study because it is not approved for early-stage disease.

The purpose of this research study is to determine if Seladelpar is effective at normalizing disease markers in subjects with primary biliary cholangitis (PBC) who are currently on ursodeoxycholic acid (UDCA) treatment or intolerant to UDCA. 

The purpose of this study is to learn how whole-body hyperthermia (achieved in a sauna) may work to decrease feelings of depression and anxiety. We know that this intervention works in adults with depression, but we do not know how it works. We also want to find out if postpartum women will find this intervention acceptable, and whether the way it works may be different in postpartum women from other people. 

The purpose of this study is to compare 2 forms of interventions for senior center clients over 60 experiencing symptoms of depression. 

Some participants enrolled in the study will receive 9 weeks of a type of psychotherapy called “Behavioral Activation” as delivered by a Master’s level mental health clinician. “Behavioral Activation” is a psychotherapy aimed at re-engaging participants in activities they once found rewarding and enjoyed but have abandoned after they developed depression.

The main purpose of this study is to determine if XEN1101 can reduce the seizure frequency and if it is safe to use. XEN1101 has been tested in other studies in epilepsy patients and it was considered to be well-tolerated. It had side effects that are similar to other antiseizure drugs commonly used to help patients with epilepsy.

XEN1101 is considered investigational, which means it is not yet approved by the U.S. Food and Drug Administration (FDA). 

Currently, the treatments of anemia in patients with myeloproliferative neoplasms (MPNs) include blood transfusions (receiving red blood cells intravenously to replace the lack of functioning red blood cells), erythropoietin stimulating agents given as injections which will help stimulate red blood cell production in the bone marrow, and sometimes steroids. These interventions are supportive but are often insufficient and temporary as they are not capable of blocking the effects of the cancer cells causing anemia. 
   

The purpose of this study is to test the benefit and safety of Canakinumab for Clonal Cytopenia of Undetermined Significance (CCUS).

This study involves the enrollment of two patient populations. For the neonatal population, we aim to develop a more accurate and efficient method for identifying abnormalities in the newborn brain using MRI imaging. MRI is the most advanced technique to examine the newborn brain, and it does not involve radiation unlike x-rays or CT. Participation will involve a 60-minute MRI scan without any sedation or contrast injections as well as approximately 2 hours dedicated to swaddling and feeding your child in preparation for the scan.