Treatment for Primary Mediastinal (Thymic) Large B-Cell Lymphoma (PMBCL) involves chemotherapy combined with an immunotherapy called rituximab. This combination is also known as the chemo-immunotherapy backbone. There are two types of chemo-immunotherapy backbone treatments for PMBCL: either R-CHOP or DA-EPOCH-R.
   
These drugs effectively treat PMBCL, but are known to cause long-term side effects at high doses. Side effects are unintended and unwanted results of treatment. Study doctors are interested in finding an effective treatment that improves the outcome of PMBCL.
   

The purpose of this study is to investigate the effect of nutrient sequencing on blood glucose levels over a 2-week period, utilizing a continuous glucose monitor (CGM) device, for Type 2 Diabetic patients being treated with metformin. 
   

Treatment for acute myeloid leukemia (AML) involves high doses of a common class of chemotherapy drugs called anthracyclines. One anthracycline drug which is effective in treating AML is daunorubicin, but high doses are known to cause long-term side effects, especially to the heart. (Side effects are unintended and unwanted results of treatment.) Study doctors are interested in finding an effective treatment for AML patients that reduces the potential for long-term side effects.
   

This is a study evaluating the safety and efficacy of the study drug Semaglutide in subjects with non-alcoholic steatohepatitis (NASH). An investigational/experimental drug is one that is currently being tested and has not been approved by the Food and Drug Administration (FDA) for sale in the United States. Experimental drugs such as Semaglutide may be tested in research studies such as this one.
   

This clinical trial is for men or women who have inadequately controlled Type 2 diabetes and are currently on stable doses of basal insulin. The purpose of this study is to learn more about the use of the Fractyl Revita System for the treatment of Type 2 diabetes for individuals who are on insulin therapy.
     
The study device, the Revita System, has not been approved for use by the Food and Drug Administration (FDA) in the United States since the device is experimental. The Revita System is commercially available in the United Kingdom. 

Repetitive transcranial magnetic stimulation (rTMS) is an FDA-cleared treatment for depression and obsessive compulsive disorder (OCD) that uses focused magnetic field pulses to stimulate target brain areas. Multiple brain targets in the prefrontal cortex have shown consistent evidence of treatment efficacy in both depression and OCD, but there are currently no established methods for selecting the optimal target site in individual patients.

This study is for men and women over 18 years of age who have suspected or known gastroesophageal reflux disease (GERD) or its associated complications, such as Barrett’s esophagus (a precancerous condition), or trouble swallowing due to esophagitis or scarring (stricture), who are undergoing diagnostic evaluation and treatment with Transoral Incisionless Fundoplication (TIF).  

The Weill Cornell Institute of Geriatric Psychiatry is conducting a research study on how brain processes affect emotion regulation, social functioning, and well-being in adults ages 45-70 years old. This study is voluntary and will not influence your regular medical care.
   
   Eligible individuals who agree to participate will take part in:
   • An initial screening interview
   • Clinical interviews
   • Cognitive assessments
   • Self-report questionnaires
   • One MRI scan
   

This study is being conducted to test if injectable, long-acting anti-HIV drugs that are given every month can be used safely and effectively in individuals who are infected with HIV and who have had problems taking daily medications in the past. This study is also being conducted to evaluate how well are these study drugs tolerated.
   

The purpose of this study is to investigate the following: