This is a study to see how effective oral naltrexone is as treatment for prolonged grief disorder (PGD).

Prolonged grief disorder (PGD) can happen after a person close to you has died within at least 6 months (12 months for children and teens). You may feel a deep longing for the person who died and become fixated on thoughts of them. This can make it hard to function at home, work, and other important settings.

The purpose of this study is to determine the safety and recommended dose of AIC100 for treating patients with advanced thyroid cancer or anaplastic thyroid cancer, and to understand the side effects that participants with your disease may have when they are treated with AIC100. There are limited treatment options available for people with these diseases.
   

The purpose of the initial (phase I) portion of this study is to find a dose level and administration schedule of the study drug, 225Ac-J591 that can be given without severe side effects. Following selection of the proper dose for each treatment regimen, the purpose of the phase II portion of the study is to test if the regimen of 225Ac-J591 leads to treatment response.
   

The purpose of this study is to:

Abnormalities in the Positive Valence System (PVS) are associated with depressive symptoms and reduced behavioral activation in mid- and late-life. This study will investigate the engagement of the PVS during exposure to social rewards, part of a novel streamlined psychotherapy for mid- and late-life depression. Use of computational modeling will enable identification of neuroimaging and behavioral profiles associated with greater treatment response, and may guide future personalization of psychotherapy.

This study will use task-based fMRI and computational modeling to examine how age and late-life depressive symptomatology influence neural network functions and resulting reward and salience processes. This is an observational study that aims to characterize abnormalities in the reward system and salience network at a single timepoint in older adults diagnosed with major depressive disorder and psychiatrically normal controls.

The purpose of this study is to measure cerebrospinal fluid (CSF) clearance in subjects with and without high blood pressure. CSF cushions the brain from impact and carries waste products from the brain to the bloodstream. This process is known as clearance. 

This study is being done to answer the following question: Can we prolong life for patients with advanced kidney cancer, by adding a drug called cabozantinib to another treatment after receiving the standard treatment? 

This registry trial is to collect information on men and women undergoing a Transjugular Intrahepatic Portosystemic Shunt or TIPS and to evaluate the long-term outcomes and complications over a 5-year period. 

The purpose of this study is to compare urinary and bowel side effects of hypofractionated radiotherapy in 20 treatments (4 weeks) to ultra- hypofractionated radiotherapy in 5 treatments (2 weeks) for prostate cancer that has returned after prostatectomy.

Learn more about the trial details in this informational video: