Altering the Tumor Microenvironment: A Phase II Study of Copper-depletion using Tetrathiomolybdate (TM) in patients (pts) with breast cancer (BC) at high risk for recurrence.

TitlePro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity.
Publication TypeJournal Article
Year of Publication2015
AuthorsStanton SE, Ward MM, Christos P, Sanford R, Lam C<, Cobham MV, Donovan D, Scheff RJ, Cigler T, >Moore A, Vahdat LT, Lane ME, Chuang E
JournalBMC Cancer
Volume15
Pagination267

CTCL Publications

Various publications the Clinical Translational Core Lab (CTCL) has contributed to over the years.

BP1001 in Combination with Low-dose Cytarabine (LDAC) in Patients with Previously Untreated (AML) Who Are Ineligible for Induction Therapy

The goal of this clinical research study is to assess whether the combination of BP1001 and cytarabine provides greater efficacy (Complete Remission [CR], Complete Remission with incomplete hematologic recovery [CRi], Complete Remission with incomplete platelet recovery [CRp]) than cytarabine alone (by historical comparison) in participants with AML that cannot or elect not to be treated with more intensive chemotherapy.

Characterization of the Microbiome to Predict Complications in Chronic Kidney Disease and End Stage Kidney Disease Patients

In this protocol, we plan to prospectively recruit subjects with chronic kidney disease or end stage kidney disease on dialysis. We will obtain stool, blood, urine (if possible), and peritoneal fluid (if on peritoneal dialysis) from the subjects on a regular basis and we will correlate whether the microbiome in these biospecimens are associated with and/or predictive of bacteremia and other complications in chronic kidney disease and end stage kidney disease.

Imaging and Pathologic Correlates for Men at Risk of Prostate Cancer

This is a retrospective and prospective study to study the use of MRI prostate imaging and other patient characteristics such as PSA and commercially available assays and its accuracy in predicting the grade and location of prostate cancer during prostate needle biopsy as well as radical prostatectomy for men going onto surgery. 

Pediatric Inflammatory Bowel Disease (IBD) Biobank

This research study is being conducted by Dr. Robbyn Sockolow, MD, the director of Pediatric Gastroenterology and Nutrition at Weill Cornell Medical College (WCM) and Komansky Children’s Hospital, and Dr. David Artis, PhD, the director of the Jill Roberts Institute for IBD at WCM. Their teams are looking for pediatric patients who are undergoing a colonoscopy or intestinal surgery.

Why is the study being done?
We are learning about the factors underlying inflammatory bowel disease with the hope that we may improve the care of pediatric patients. 

Research Registry - Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry (IPF-PRO)

The Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry (IPF-PRO)  aims to:

  • Collect information regarding the natural history of IPF and healthcare interactions
  • Describe quality of life of IPF participants with patient reported questionnaires
  • Assess the methods of treatment of participants
  • Collect blood specimens for future research projects

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2)

CREST-2 is a study for people who have narrowing of their carotid artery without symptoms caused by that artery like small strokes or temporary strokes. Temporary strokes are often called transient ischemic attacks or TIAs. The purpose of this study is to compare intensive medical management alone to intensive medical management plus a procedure to reopen the carotid artery in the neck for treatment of plaque buildup.