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Joint Clinical Trials Office

Excessive Iron in the Lung Implicated in COPD

Dr. Augugstine Choi

Excessive iron buildup in the lungs could be a major cause of chronic obstructive pulmonary disease, Weill Cornell Medicine scientists find in a new study. The investigators also believe that they have identified the culprit for the excess: A gene they previously found to increase patients' susceptibility to the progressive lung disease.

A Married Pair of Social Scientists Promotes Compassionate Care for Cancer Patients at the End of Life - And the Loved Ones They Leave Behind

Drs. Holly Prigerson and Paul Maciejewski Photo credit: John Abbott

Sociologist Dr. Holly Prigerson was an assistant professor at Yale in 1999 when she was summoned to the bedside of her father, whose pancreatic cancer had taken a turn for the worse. Even then, Dr.

Repository of Novel Analytes Leading to Autoimmune, Inflammatory, and Diabetic Nephropathies (RENAL AID)

The purpose of this research biorepository study is to collect demographic, clinical, biochemical, histological, and genetic (RNA) data and samples from a large population of subjects with a variety of renal disease states, including diabetic, inflammatory, autoimmune and transplant related renal conditions, in order to assess for factors that may be associated with the progression of disease, the incidence of complications, (including renal failure), and the responses to therapy.  In addition, the biorepository will include the collection of data and samples from control subjects without e

Development of Gene Expression Monitoring (GEM) Bio-Bank to Study Non-Invasive Bio-markers that Diagnose and Anticipate Post-transplant Complications

In this study, we propose to collect urine, blood and stool at time of any biopsy as well as during their routine post-transplant outpatient visits. Samples will be stored in the Gene Expression Monitoring (GEM) laboratory funded by Dr. Manikkam Suthanthiran’s NIH and Qatar National Research Fund support and will be used in future studies to test specific hypothesis related to transplant kidney dysfunction relating to rejection, chronic injury, viral and bacterial infections, immune status, complications of immune therapy and post-transplant malignancy.

Key eligibility:

Gene Expression Monitoring of Renal Allograft Status (GEM Tissue)

The purpose of this study is to learn more about a patient’s transplant and related complications. We will develop tests for assessing the status of the kidney transplant, as well as any potential complications. The study will help u to come up with ways to anticipate, diagnose and prognosticate problems associated with kidney transplants. The tissue collected in this study will be stored in a repository (database) to analyze for the presence of various markers believed to be involved in allograft dysfunction.

Key eligibility:

Here's how virtual reality could help doctors treat cancer

Olivier Elemento

Virtual reality headsets are not yet commonplace, but they already have the potential to revolutionize many aspects of our lives—how we view entertainment like movies and video games, how we see the world, and even how we do science.

Among keys to curing cancer, academic medical centers loom large

Dr. Laurie H. Glimcher Stephen and Suzanne Weiss Dean of Weill Cornell Medical College & Provost for Medical Affairs, Cornell University

The moonshot to cure cancer will need to enlist the nation’s academic medical centers, our most powerful incubators of medical innovation. These institutions are already developing – and putting into use –some of the most promising therapies.

Experimental Therapy Could Treat Diabetes and Fatty Liver

An investigational drug (AC261066) given to mice with diabetes restores normal blood sugar levels, effectively treating the disease Image credit: Gudas Lab

A new investigational therapy could be a major breakthrough in the treatment of both diabetes and fatty liver, according to Weill Cornell Medicine investigators.

WEILL CORNELL PHYSICIAN-SCIENTISTS AND CORNELL UNIVERSITY ENGINEERS COLLABORATE — AND PATIENTS BENEFIT

BY BETH SAULNIER 

From foe to friend: Transforming tumors into personalized vaccines

Dr. Silvia Formenti
Dr. Silvia Formenti

Radiation has long been a pillar of cancer care, alongside surgery and chemotherapy. But what if it could be used in a new way - to trigger a set of immune responses that transform tumors into killing machines, a type of in situ vaccine?