Newly diagnosed post-menopausal women with clinical stage II-III, HR+HER2- breast cancer are eligible for this randomized trial that will be concurrently open at five US academic institutions. Patients receiving 4 months of standard neoadjuvant hormonal therapy with letrozole are randomly assigned to one of 4 arms of the trial testing focal hypo-fractionated RT alone or with immunotherapy combinations. 

The purpose of this study is to investigate the relationships between neuroinflammation and Alzheimer’s disease (AD). Neuroinflammation is inflammation that occurs in the brain. Certain cells in the brain called microglia are involved in regulating inflammation. The accumulation of certain abnormal proteins, such as tau, have been implicated in AD. Tau may promote inflammatory reactions by microglial cells.

The purpose of this clinical study is to collect data from patients to evaluate the safety and effectiveness of the AtriCure CryoICE Cryoablation System for the treatment of persistent and long-standing persistent atrial fibrillation during open-heart surgery. 

The objective of this observational trial is to determine time to valve failure due to valve deterioration requiring re-intervention and collect/investigate early potential predictors of valve durability in RESILIA tissue valves. 

This behavioral study will examine how different self-report and clinical rating scales correlate with motivation processes in middle-aged and older adults with depression. The goal is to identify simple measures for characterizing abnormalities in motivation in depressed patients that can be used in the community. Administration of these measures at the outset and during treatment will allow community clinicians to optimize the selection and timing of behavioral interventions. 

This study aims to develop and validate data-driven computational models of the temporal coordination and production of NVC behaviors during dyadic social interactions in TD, ASD, and DD children. We also aim to identify the fine-grained properties of coordination of motor movement and NVC captured by computational models that are most predictive of diagnostic group and one-year language outcomes. Finally, we will explore novel NVC coordination patterns via bottom-up clustering of motor 

This study has the goal of furthering our understanding of the longitudinal course of autism spectrum disorder (ASD). Specifically, we propose a longitudinal study of young children with ASD (2-3 years) to identify the neurobiological underpinnings of early developmental changes in restricted repetitive behavior/interests (RRB), one of the most clinically impairing aspects of ASD - and their predictive contribution to later function. 

This 9-session behavioral intervention was developed to address the need of primary care interventions for people experiencing chronic pain and depression, which co-exist in late and mid-life, contributing to increased disability, high health care costs, psychiatric comorbidities, and suicide. Participants will have clinically significant depression and suffer from chronic pain and receive either 9 weeks of RELIEF therapy or Usual Care. Research assessments will be conducted at entry, and at 6, 9, and 12 weeks. 

This study has the goal of furthering our understanding of measuring changes in the presentation of Autism Spectrum Disorder (ASD) symptoms over the lifetime. Specifically, we will measure subtle changes in core symptoms of ASD, including social skills and repetitive and restricted behaviors/interests through the Brief Observation of Social Communication Change (BOSCC). While other diagnostic tests (e.g. ADOS-2, ADI-R) measure these clinical symptoms, they are less sensitive to subtle changes across time that may be a result of intervention, therapy, or other developmental changes.

This study aims to compare the effects of 15 sessions (12 weekly in first 12 weeks and 3 monthly booster sessions afterwards) of PATH-MCI (Problem Adaptation Therapy for Mild Cognitive Impairment) vs. ST-CI (Supportive Therapy for Cognitively Impaired Older Adults). Participants receive either 15 weeks of PATH-MCI or Supportive Therapy. Research assessments will be conducted at entry into the study, 6, 12, 24, 36, and 52 weeks.