Could ‘retromer' be the key to Alzheimer's treatment?
A key to cellular function — and to life itself — is the movement of proteins and lipids within a cell. As these substances follow their paths, a part of the cell called the endosome acts as the traffic hub, sorting them to be recycled, diverted, secreted or degraded. When the endosome sends them to be recycled back to the cell surface, a complex of proteins plays a role like that of a school crossing guard...
