Depression is the second leading cause of disability worldwide, due partly to the fact that existing antidepressants are not effective for all patients and it is often challenging to match individual patients to the treatments that are most likely to help them. This study will test a new strategy for using fMRI brain scans to predict antidepressant response and assist clinicians in choosing antidepressant treatments. Transcranial magnetic stimulation targeting one of two depression-related brain areas is most likely to benefit an individual patient. 

The goal of this study is to learn about changes in the brain of older adults that occur during treatment for depression with two types of psychotherapy called Engage therapy and supportive therapy, and how they differ from one another.

Engage therapy is designed to help individuals with depression become involved in activities they previously enjoyed but have not been participating in since developing depression. In Engage therapy, individuals with depression work with a therapist to develop "action plans" to pursue rewarding activities of their choice.

The purpose of this study is to compare thinking, emotions, and brain function in older adults without a history of psychiatric illness to older adults who are receiving treatment for depression in our other studies. This research is being done to help develop, understand, and improve treatments for depression in older adults. In order to help benefit people with depression in the future, we also need to evaluate older adults with no history of depression.

This clinical trial is for men age 18 and older with metastatic castration-resistant prostate cancer (mCRPC), which is prostate cancer that no longer responds to hormone therapy. The cancer spreads (metastasizes) to the bones. 

Standard treatment for advanced germ cell tumors includes three chemotherapy drugs called BEP (Bleomycin, Etoposide, and cisPlatin). BEP is given with a drug called pegfilgrastim or filgrastim which makes white blood cells grow. These drugs are given over the course of 3 weeks. Previous research has been done in studying BEP to improve the outcome of patients with poor-risk GCTs. One method that was tried is called dose intensification. This method works by giving the dose of chemotherapy drugs over a shorter length of time.

Breast cancer subjects with multiple brain metastases are often initially treated with stereotactic radiosurgery (SRS), a non-surgical radiation technique used to treat small brain tumors or whole brain radiation therapy (WBRT). When initially managed with SRS, subjects often develop new brain metastases in the untreated brain, requiring additional SRS procedures and, eventually, WBRT, which is often associated with significant neurocognitive sequelae (headache, nausea, dizziness, confusion, memory loss and motor dysfunction).

This is an observational study for men and women who have a body mass index (BMI) of greater than 30 kg/m2 and have a history of liver or gastrointestinal (GI) problems. 

This clinical trial is open to adult men and women age 60 and under who are newly diagnosed with FLT3 Mutated Acute Myeloid Leukemia (AML). 

The purpose of this study is to test the safety of the combination of multiple drugs: brentuximab vedotin which is approved for use in relapsed Hodgkin lymphoma, ipilimumab and nivolumab both drugs which stimulate your immune system, and which are approved for use in other cancers, but are investigational for Hodgkin lymphoma.

This is an observational study. This study is for men and women who will undergo a standard of care advanced endoscopic therapeutic procedure and subsequent follow‐up clinic visits.