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CT Open to Enrollment

Fecal Microbiota Transplantation National Registry

This registry study is being done to collect information on fecal microbiota transplant (FMT). Eligible participants are men or women who are being seen in the clinic as an FMT recipient or FMT donor or receiving other gut-related microbiota product. 

(CLONEVO): Cell cycLe inhbitiON to target the EVolution of urOthelial cancer

This is a clinical trial for men and women age 18 and older diagnosed with advanced bladder cancer who are not eligible or choose not to receive chemotherapy before standard-of-care surgery for bladder cancer

The purpose of this study is to test the safety of the study drug, abemaciclib, and see what effects (good and bad) it has in muscle-invasive bladder cancer. 

Zoster Eye Disease Study (ZEDS)

ZEDS is a clinical trial investigating whether long-term treatment with a pill, Valacyclovir, will help reduce eye disease and/or chronic pain in patients with shingles affecting the eye. 

Posterior Left Pericardiotomy for the Prevention of Postoperative Atrial Fibrillation After Cardiac Surgery

The primary objective of the trial is to determine the incidence of Post-Operative Atrial Fibrillation (POAF) after cardiac surgery when posterior pericardiotomy is performed. 

ROMA Trial

The purpose of this study is to determine the effect of single vs. multiple arterial revascularization (this is the restoration of blood flow to an organ) for patients undergoing coronary artery bypass surgery. 

PROMIS as a novel patient reported outcome (PRO) tool in adult patients with congenital blood disorders

The purpose of this study is to evaluate a new type of patient-reported outcome tool that can be completed on an electronic device and will provide information about the quality of your life and health as it relates to your disease. We hope to learn about the natural history of congenital blood disorders and how they affect your life. 
    

Comprehensive Care in Patients with Thalassemia and Severe Congenital Anemias

 The purpose of this study is to continue to learn about impact of comprehensive care on the natural history of patients with thalassemia (Cooley’s anemia) and other severe anemias requiring periodic or regular red blood cell transfusions. We will collect data on guideline recommended measures obtained from the standard of care: routine tests (EKG, Echocardiogram, Holter Monitor, MRI, eye exam, hearing test, x-ray, bone studies, pulmonary function study) done once a year and monthly blood draw and urinalysis for complete blood count, chemistries, and iron studies.

Safety of Immunosuppression in A Prospective Cohort of Inflammatory Bowel Disease Patients With a History of Cancer (SAPPHIRE)

This is a prospective, multi-center, observational study designed to determine if specific agents used for treatment of inflammatory bowel disease (IBD) are associated with the development of new or recurrent cancer in patients with IBD and a history of cancer.

 Commitments for enrollment include:

RPC01-3102: A Phase 3, Multicenter, Open-Label Extension Trial of Oral RPC1063 as Therapy for Moderate to Severe Ulcerative Colitis. (Extension study for RPC01-3101)

The purpose of this study is to see if long-term use of the investigational drug RPC1063 (ozanimod) is safe and effective for the possible treatment of UC. 
    
RPC1063 is a chemical compound that is thought to act on the immune system by making certain types of white blood cells (lymphocytes including T cells) stay in the lymph nodes and other places in the body, keeping them away from sites of inflammation.