Effective treatment to prevent disability MS has been largely non-existent due to a poor understanding of the relevant pathophysiologic mechanisms. The purpose of the study is use novel PET and MRI techniques to study acute multiple sclerosis (MS) lesion. We will use a Magnetic Resonance Imaging (MRI) imaging sequence (programmed set of parameters and magnetic gradients) which will measure myelin and iron within lesions. Positron Emission Tomography (PET) is another test which may be more detailed information about factors causing damage within MS lesions. MRI is a test approved by FDA.

This study aims to determine if apixaban is superior to aspirin for prevention of stroke or hemorrhage or death in patients with recent intracerebral hemorrhage or atrial fibrillation.

Parkinson's disease affects 1 in 100 people over the age of 65, but the time between Parkinson's disease onset and diagnosis can be many months or years. Interestingly, pathological hallmarks of Parkinson's in the brain can also be seen in the neurons in the gut and symptoms like constipation often precede the onset of tremor and incoordination by many years. It is now believed that Parkinson's disease may begin in the gut, at least in some people.

The study is investigating a link between high-risk plaque and cardioembolic sources among patients with stroke of unknown causes. This observational study uses an MRI protocol to detect bleeds within plaque, a marker of high-risk plaque. There is an additional PET/MRI that patients can opt into to more closely observe the plaque within the carotid arteries.

This study includes optional parts which will have financial compensation.

Newly diagnosed post-menopausal women with clinical stage II-III, HR+HER2- breast cancer are eligible for this randomized trial that will be concurrently open at five US academic institutions. Patients receiving 4 months of standard neoadjuvant hormonal therapy with letrozole are randomly assigned to one of 4 arms of the trial testing focal hypo-fractionated RT alone or with immunotherapy combinations. 

The purpose of this study is to investigate the relationships between neuroinflammation and Alzheimer’s disease (AD). Neuroinflammation is inflammation that occurs in the brain. Certain cells in the brain called microglia are involved in regulating inflammation. The accumulation of certain abnormal proteins, such as tau, have been implicated in AD. Tau may promote inflammatory reactions by microglial cells.

This study aims to compare the effects of 15 sessions (12 weekly in first 12 weeks and 3 monthly booster sessions afterwards) of PATH-MCI (Problem Adaptation Therapy for Mild Cognitive Impairment) vs. ST-CI (Supportive Therapy for Cognitively Impaired Older Adults). Participants receive either 15 weeks of PATH-MCI or Supportive Therapy. Research assessments will be conducted at entry into the study, 6, 12, 24, 36, and 52 weeks.

The purpose of this study is to evaluate physical reactions associated with PTSD that develops due to the experience of military sexual trauma.

We are conducting a randomized proof-of-concept study to assess the efficacy of virtual reality (VR) vs standard of care in 50 adult patients in the NewYork-Presbyterian Burn Unit. The participants who are randomized to receive the virtual reality intervention will also receive opioids, which is the standard of care and is known to be effective.

The purpose of this study is to treat symptoms of posttraumatic stress disorder (PTSD) resulting from burn trauma using traditional treatment.