This research study is being conducted by Dr. Robbyn Sockolow, MD, the director of Pediatric Gastroenterology and Nutrition at Weill Cornell Medical College (WCM) and Komansky Children’s Hospital, and Dr. David Artis, PhD, the director of the Jill Roberts Institute for IBD at WCM. Their teams are looking for pediatric patients who are undergoing a colonoscopy or intestinal surgery.

Why is the study being done?
We are learning about the factors underlying inflammatory bowel disease with the hope that we may improve the care of pediatric patients. 

The Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry (IPF-PRO)  aims to:

• Collect information regarding the natural history of IPF and healthcare interactions
• Describe quality of life of IPF participants with patient reported questionnaires
• Assess the methods of treatment of participants
• Collect blood specimens for future research projects

CREST-2 is a study for people who have narrowing of their carotid artery without symptoms caused by that artery like small strokes or temporary strokes. Temporary strokes are often called transient ischemic attacks or TIAs. The purpose of this study is to compare intensive medical management alone to intensive medical management plus a procedure to reopen the carotid artery in the neck for treatment of plaque buildup.

This clinical trial is for men and women with high-grade gliomas. Glucose (sugar) is thought to be a contributor to tumor growth. The ketogenic diet (a high fat, low carbohydrate diet) and metformin (a drug approved by the Food and Drug Administration to treat type 2 diabetes) are both known to lower blood glucose levels. 
    

The purpose of this study is to better understand the changes in cholesterol levels, the blood vessels, and overall health of children and adults with homozygous familial hypercholesterolemia (hoFH).

Homozygous familial hypercholesterolemia is a rare (~1 in 1,000,000) inherited (genetic) disorder that is usually due to a double mutation in the gene for the Low Density Lipoprotein (LDL) receptor.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease, affecting more than 500,000 people in the U.S. and 10 million people worldwide. ADPKD is the 4th most common cause of kidney failure requiring dialysis and/or transplantation. Over half of all ADPKD patients develop kidney failure by age 60 years, although age of onset of kidney disease varies widely, even among members of the same family.

The purpose of this research biorepository study is to collect demographic, clinical, biochemical, histological, and genetic (RNA) data and samples from a large population of subjects with a variety of renal disease states, including diabetic, inflammatory, autoimmune and transplant related renal conditions, in order to assess for factors that may be associated with the progression of disease, the incidence of complications, (including renal failure), and the responses to therapy.  In addition, the biorepository will include the collection of data and samples from control subjects without e

In this study, we propose to collect urine, blood and stool at time of any biopsy as well as during their routine post-transplant outpatient visits. Samples will be stored in the Gene Expression Monitoring (GEM) laboratory funded by Dr. Manikkam Suthanthiran’s NIH and Qatar National Research Fund support and will be used in future studies to test specific hypothesis related to transplant kidney dysfunction relating to rejection, chronic injury, viral and bacterial infections, immune status, complications of immune therapy and post-transplant malignancy.

Key eligibility:

The purpose of this study is to learn more about a patient’s transplant and related complications. We will develop tests for assessing the status of the kidney transplant, as well as any potential complications. The study will help u to come up with ways to anticipate, diagnose and prognosticate problems associated with kidney transplants. The tissue collected in this study will be stored in a repository (database) to analyze for the presence of various markers believed to be involved in allograft dysfunction.

Key eligibility:

This pilot study is collaboration between the Weill Cornell Medical College, Department of Genetic Medicine and Yale University and will examine the pathways involved in allergic response, primarily in food allergy; specifically peanut allergy.