CT Open to Enrollment

Pembrolizumab and Stereotactic Radio Surgery (SRS) of Selected Brain Metastases in Breast Cancer Patients

Breast cancer subjects with multiple brain metastases are often initially treated with stereotactic radiosurgery (SRS), a non-surgical radiation technique used to treat small brain tumors or whole brain radiation therapy (WBRT). When initially managed with SRS, subjects often develop new brain metastases in the untreated brain, requiring additional SRS procedures and, eventually, WBRT, which is often associated with significant neurocognitive sequelae (headache, nausea, dizziness, confusion, memory loss and motor dysfunction).

Long term Outcomes of Obese Patients with Gastrointestinal Complications of Disease

This is an observational study for men and women who have a body mass index (BMI) of greater than 30 kg/m2 and have a history of liver or gastrointestinal (GI) problems. 

A Phase 1 Study With an Expansion Cohort/Randomized Phase 2 Study of the Combinations of Ipilimumab, Nivolumab and Brentuximab Vedotin in Patients With Relapsed/Refractory Hodgkin Lymphoma

The purpose of this study is to test the safety of the combination of multiple drugs: brentuximab vedotin which is approved for use in relapsed Hodgkin lymphoma, ipilimumab and nivolumab both drugs which stimulate your immune system, and which are approved for use in other cancers, but are investigational for Hodgkin lymphoma.

Advanced Endoscopic Therapies (AETs): A Retrospective and Prospective Multicenter Registry

This is an observational study. This study is for men and women who will undergo a standard of care advanced endoscopic therapeutic procedure and subsequent follow‐up clinic visits. 
    

TARGET–NASH: A 5-year Longitudinal Observational Study of Patients with Non-Alcoholic Fatty Liver or Non-Alcoholic Steatohepatitis

This is an observational study. This study is for men and women who have nonalcoholic fatty liver (NAFL), which is storage of fat in the liver, or NASH (nonalcoholic steatohepatitis) which is a form of NAFL liver disease that includes irritation or inflammation of the liver due to fat. 

A Gene-Transfer, Open-Label, Dose-Escalation Study of SPK-8011 [Recombinant Adeno-Associated Viral Vector with B-Domain Deleted Human Factor VIII Gene] in Individuals with Hemophilia A

Hemophilia A is a condition in which blood is unable to clot effectively. It is caused by a mutation or deletion in the gene that is responsible for producing blood-clotting factor VIII protein. Individuals with hemophilia A suffer from repeated bleeding episodes, often into the joints, which can cause chronic joint disease and sometimes results in death due to the inability of the blood to clot efficiently. This chronic joint disease can have significant physical, psychosocial, and quality-of-life effects, including financial burden.

IRONMAN: International Registry for Men with Advanced Prostate Cancer

This clinical trial is for patients with Advanced Prostate Cancer. The purpose of this study is to learn more about prostate cancer and:

Fecal Microbiota Transplantation National Registry

This registry study is being done to collect information on fecal microbiota transplant (FMT). Eligible participants are men or women who are being seen in the clinic as an FMT recipient or FMT donor or receiving other gut-related microbiota product. 

(CLONEVO): Cell cycLe inhbitiON to target the EVolution of urOthelial cancer

This is a clinical trial for men and women age 18 and older diagnosed with advanced bladder cancer who are not eligible or choose not to receive chemotherapy before standard-of-care surgery for bladder cancer

The purpose of this study is to test the safety of the study drug, abemaciclib, and see what effects (good and bad) it has in muscle-invasive bladder cancer.